6T13

CRYSTAL STRUCTURE OF GLUCOCEREBROSIDASE IN COMPLEX WITH A PYRROLOPYRAZINE

6T13 の概要

• エントリーDOI: 10.2210/pdb6t13/pdb
• 分子名称: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (10 entities in total)
• 機能のキーワード: gcase, glycosidase, cerezyme, hydrolysis, hydrolase, glycosylceramidase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 243175.56

構造登録者

Benz, J.,Ehler, A.,Hug, M.,Huber, S.,Rufer, A.C.,Guba, W.,Jagasia, R.,Hofmann, E.C.,Rodriguez Sarmiento, R.M. (登録日: 2019-10-03, 公開日: 2020-12-23, 最終更新日: 2024-01-24)

• 主引用文献: Benz, J.,Rufer, A.C.,Huber, S.,Ehler, A.,Hug, M.,Topp, A.,Guba, W.,Hofmann, E.C.,Jagasia, R.,Rodriguez Sarmiento, R.M.; Novel beta-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.; Angew.Chem.Int.Ed.Engl., 60:5436-5442, 2021; PubMed: 33238058; DOI: 10.1002/anie.202013890

実験手法

X-RAY DIFFRACTION (1.85 Å)