6SWS

The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway

Summary for 6SWS

Entry DOI	10.2210/pdb6sws/pdb
Descriptor	Phosphoinositide 3-kinase adapter protein 1 (1 entity in total)
Functional Keywords	dbb, tig/ipt, transcription factor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	5
Total formula weight	62370.35
Authors	Lauenstein, J.U.,Scherm, M.J.,Udgata, A.,Moncrieffe, M.C.,Fisher, D.,Gay, N.J. (deposition date: 2019-09-23, release date: 2020-02-19, Last modification date: 2020-04-15)
Primary citation	Lauenstein, J.U.,Scherm, M.J.,Udgata, A.,Moncrieffe, M.C.,Fisher, D.I.,Gay, N.J. Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain. J Immunol., 204:2269-2276, 2020 Cited by PubMed: 32198144 DOI: 10.4049/jimmunol.1901210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation