6SVM
Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate, L-Glu, and UDP-GalNAc
Summary for 6SVM
Entry DOI | 10.2210/pdb6svm/pdb |
Descriptor | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, ... (6 entities in total) |
Functional Keywords | glutamine fructose-6-phosphate aminotransferase, gfat, ntn hydrolase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 157322.73 |
Authors | Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. (deposition date: 2019-09-18, release date: 2020-01-15, Last modification date: 2024-01-24) |
Primary citation | Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11:687-687, 2020 Cited by PubMed: 32019926DOI: 10.1038/s41467-020-14524-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.481 Å) |
Structure validation
Download full validation report![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)
![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)