6SUY

Yeast cytochrome c in complex with an octa-anionic calix[4]arene

6SUY の概要

• エントリーDOI: 10.2210/pdb6suy/pdb
• 分子名称: Cytochrome c iso-1, HEME C, octa-anionic calix[4]arene, ... (6 entities in total)
• 機能のキーワード: protein recognition, porous assembly, supramolecular scaffolds, molecular glue, oxidoreductase
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27800.61

構造登録者

Alex, J.M.,Crowley, P.B. (登録日: 2019-09-17, 公開日: 2020-01-15, 最終更新日: 2024-11-06)

主引用文献

Alex, J.M.,Brancatelli, G.,Volpi, S.,Bonaccorso, C.,Casnati, A.,Geremia, S.,Crowley, P.B.
Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene.
Org.Biomol.Chem., 18:211-214, 2020

PubMed Abstract: Sulfonato-calix[n]arenes (sclxn) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclx4mc) in complex with proteins. Two crystal structures of sclx4mc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx8 and sclx6 but not with sclx4, suggesting that the ligand charge is a determining factor.

PubMed: 31808772
DOI: 10.1039/c9ob02275a

実験手法

X-RAY DIFFRACTION (1.75 Å)