6STG

Human Rab8a phosphorylated at Ser111 in complex with GPPNP

Summary for 6STG

• Entry DOI: 10.2210/pdb6stg/pdb
• Related: 4LHW
• Descriptor: Ras-related protein Rab-8A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: parkinson disease, phosphorylation, small g-protein, sf3 motif, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 42666.54

Authors

Vieweg, S.,Mulholland, K.,Braeuning, B.,Kachariya, N.,Lai, Y.,Toth, R.,Sattler, M.,Groll, M.,Itzen, A.,Muqit, M.M.K. (deposition date: 2019-09-10, release date: 2020-04-22, Last modification date: 2024-01-24)

• Primary citation: Vieweg, S.,Mulholland, K.,Brauning, B.,Kachariya, N.,Lai, Y.C.,Toth, R.,Singh, P.K.,Volpi, I.,Sattler, M.,Groll, M.,Itzen, A.,Muqit, M.M.K.; PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.; Biochem.J., 477:1651-1668, 2020; PubMed: 32227113; DOI: 10.1042/BCJ20190664

Experimental method

X-RAY DIFFRACTION (2.5 Å)