6STG
Human Rab8a phosphorylated at Ser111 in complex with GPPNP
Summary for 6STG
Entry DOI | 10.2210/pdb6stg/pdb |
Related | 4LHW |
Descriptor | Ras-related protein Rab-8A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | parkinson disease, phosphorylation, small g-protein, sf3 motif, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 42666.54 |
Authors | Vieweg, S.,Mulholland, K.,Braeuning, B.,Kachariya, N.,Lai, Y.,Toth, R.,Sattler, M.,Groll, M.,Itzen, A.,Muqit, M.M.K. (deposition date: 2019-09-10, release date: 2020-04-22, Last modification date: 2024-01-24) |
Primary citation | Vieweg, S.,Mulholland, K.,Brauning, B.,Kachariya, N.,Lai, Y.C.,Toth, R.,Singh, P.K.,Volpi, I.,Sattler, M.,Groll, M.,Itzen, A.,Muqit, M.M.K. PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72. Biochem.J., 477:1651-1668, 2020 Cited by PubMed: 32227113DOI: 10.1042/BCJ20190664 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report