6SRX
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021158
This is a non-PDB format compatible entry.
Summary for 6SRX
Entry DOI | 10.2210/pdb6srx/pdb |
Related | 6SRV 6SS0 6SS2 6SS4 6SS5 6SS6 6TUL |
Descriptor | Fab C0021158 heavy chain (IgG1), Fab C0021158 light chain (IgG1), ACETATE ION, ... (5 entities in total) |
Functional Keywords | arginase-2 inhibitor, igg, antigen-binding fragment, protein binding |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 95877.72 |
Authors | Burschowsky, D.,Addyman, A.,Fiedler, S.,Groves, M.,Haynes, S.,Seewooruthun, C.,Carr, M. (deposition date: 2019-09-06, release date: 2020-06-10, Last modification date: 2024-01-24) |
Primary citation | Austin, M.,Burschowsky, D.,Chan, D.T.Y.,Jenkinson, L.,Haynes, S.,Diamandakis, A.,Seewooruthun, C.,Addyman, A.,Fiedler, S.,Ryman, S.,Whitehouse, J.,Slater, L.H.,Hadjinicolaou, A.V.,Gileadi, U.,Gowans, E.,Shibata, Y.,Barnard, M.,Kaserer, T.,Sharma, P.,Luheshi, N.M.,Wilkinson, R.W.,Vaughan, T.J.,Holt, S.V.,Cerundolo, V.,Carr, M.D.,Groves, M.A.T. Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action. Mabs, 12:1801230-1801230, Cited by PubMed: 32880207DOI: 10.1080/19420862.2020.1801230 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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