6SQP

Crystal structure of Cat MDM2-S429E RING domain homodimer

Summary for 6SQP

• Entry DOI: 10.2210/pdb6sqp/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, ZINC ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: mdm2, mdmx, ubiquitin ligase, e3, phosphorylation, ligase
• Biological source: Felis catus (Cat); More
• Total number of polymer chains: 4
• Total formula weight: 30628.46

Authors

Magnussen, H.M.,Ahmed, S.F.,Huang, D.T. (deposition date: 2019-09-04, release date: 2020-05-06, Last modification date: 2024-01-24)

• Primary citation: Magnussen, H.M.,Ahmed, S.F.,Sibbet, G.J.,Hristova, V.A.,Nomura, K.,Hock, A.K.,Archibald, L.J.,Jamieson, A.G.,Fushman, D.,Vousden, K.H.,Weissman, A.M.,Huang, D.T.; Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.; Nat Commun, 11:2094-2094, 2020; PubMed: 32350255; DOI: 10.1038/s41467-020-15783-y

Experimental method

X-RAY DIFFRACTION (1.21 Å)