6SOU

Fragment N13565a in complex with MAP kinase p38-alpha

Summary for 6SOU

Entry DOI	10.2210/pdb6sou/pdb
Descriptor	Mitogen-activated protein kinase 14, CHLORIDE ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	fbdd, fragment based drug design, p38, mapk14, kinase, transferase., transferase
Biological source	Mus musculus (House mouse)
Total number of polymer chains	1
Total formula weight	44545.27
Authors	Nichols, C.E.,De Nicola, G.F. (deposition date: 2019-08-29, release date: 2019-10-02, Last modification date: 2024-01-24)
Primary citation	Nichols, C.,Ng, J.,Keshu, A.,Kelly, G.,Conte, M.R.,Marber, M.S.,Fraternali, F.,De Nicola, G.F. Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63:7559-7568, 2020 Cited by PubMed: 32543856 DOI: 10.1021/acs.jmedchem.0c00403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation