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6SOT

Fragment N11290a in complex with MAP kinase p38-alpha

Summary for 6SOT
Entry DOI10.2210/pdb6sot/pdb
DescriptorMitogen-activated protein kinase 14, 1-(4-methylphenyl)pyrrolidine-2,5-dione, CHLORIDE ION, ... (7 entities in total)
Functional Keywordsfbdd, fragment based drug design, p38, mapk14, kinase, transferase., transferase
Biological sourceMus musculus (Mouse)
Total number of polymer chains1
Total formula weight44515.78
Authors
Nichols, C.E.,De Nicola, G.F. (deposition date: 2019-08-29, release date: 2019-10-02, Last modification date: 2024-01-24)
Primary citationNichols, C.,Ng, J.,Keshu, A.,Kelly, G.,Conte, M.R.,Marber, M.S.,Fraternali, F.,De Nicola, G.F.
Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63:7559-7568, 2020
Cited by
PubMed: 32543856
DOI: 10.1021/acs.jmedchem.0c00403
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.54 Å)
Structure validation

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