6SMN

A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with methotrexate

6SMN の概要

• エントリーDOI: 10.2210/pdb6smn/pdb
• 分子名称: Serine hydroxymethyltransferase 2, mitochondrial, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: shmt, antifolate, transferase
• 由来する生物種: Arabidopsis thaliana (Mouse-ear cress); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 220319.08

構造登録者

Ruszkowski, M.,Sekula, B.,Dauter, Z. (登録日: 2019-08-22, 公開日: 2020-01-08, 最終更新日: 2024-01-24)

• 主引用文献: Ruszkowski, M.,Sekula, B.,Ruszkowska, A.,Contestabile, R.,Nogues, I.,Angelaccio, S.,Szczepaniak, A.,Dauter, Z.; Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models.; Sci Rep, 9:19614-19614, 2019; PubMed: 31873125; DOI: 10.1038/s41598-019-56043-4

実験手法

X-RAY DIFFRACTION (1.63 Å)