6SM2
Mutant immunoglobulin light chain causing amyloidosis (Pat-1)
Summary for 6SM2
Entry DOI | 10.2210/pdb6sm2/pdb |
Related | 6SM1 |
Descriptor | Pat-1 (2 entities in total) |
Functional Keywords | al amyloidosis, antibody folding, protein stability, dynamics, protein fibril |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 23529.52 |
Authors | Kazman, P.,Vielberg, M.-T.,Cendales, M.D.P.,Hunziger, L.,Weber, B.,Hegenbart, U.,Zacharias, M.,Koehler, R.,Schoenland, S.,Groll, M.,Buchner, J. (deposition date: 2019-08-21, release date: 2020-03-18) |
Primary citation | Kazman, P.,Vielberg, M.T.,Pulido Cendales, M.D.,Hunziger, L.,Weber, B.,Hegenbart, U.,Zacharias, M.,Kohler, R.,Schonland, S.,Groll, M.,Buchner, J. Fatal amyloid formation in a patient's antibody light chain is caused by a single point mutation. Elife, 9:-, 2020 Cited by PubMed: 32151314DOI: 10.7554/eLife.52300 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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