6SLZ

Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist

Summary for 6SLZ

• Entry DOI: 10.2210/pdb6slz/pdb
• Descriptor: Nuclear receptor ROR-gamma, (2~{S})-1-[2,4-bis(chloranyl)-3-[[2-methyl-4-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]carbonyl-~{N}-methyl-pyrrolidine-2-carboxamide (3 entities in total)
• Functional Keywords: rorg, inverse agonist, nuclear hormone receptor, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 58523.30

Authors

Amaudrut, J.,Argiriadi, M.A.,Barth, M.,Breinlinger, E.C.,Calderwood, D.J.,Cusack, K.P.,Kort, M.E.,Montalbetti, C.,Potin, D.,Poupardin, O.,Spitzer, L. (deposition date: 2019-08-21, release date: 2020-09-09, Last modification date: 2024-01-24)

• Primary citation: Amaudrut, J.,Argiriadi, M.A.,Barth, M.,Breinlinger, E.C.,Calderwood, D.J.,Cusack, K.P.,Kort, M.E.,Montalbetti, C.,Potin, D.,Poupardin, O.,Spitzer, L.; Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)