6SLZ

Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist

6SLZ の概要

• エントリーDOI: 10.2210/pdb6slz/pdb
• 分子名称: Nuclear receptor ROR-gamma, (2~{S})-1-[2,4-bis(chloranyl)-3-[[2-methyl-4-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]carbonyl-~{N}-methyl-pyrrolidine-2-carboxamide (3 entities in total)
• 機能のキーワード: rorg, inverse agonist, nuclear hormone receptor, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58523.30

構造登録者

Amaudrut, J.,Argiriadi, M.A.,Barth, M.,Breinlinger, E.C.,Calderwood, D.J.,Cusack, K.P.,Kort, M.E.,Montalbetti, C.,Potin, D.,Poupardin, O.,Spitzer, L. (登録日: 2019-08-21, 公開日: 2020-09-09, 最終更新日: 2024-01-24)

• 主引用文献: Amaudrut, J.,Argiriadi, M.A.,Barth, M.,Breinlinger, E.C.,Calderwood, D.J.,Cusack, K.P.,Kort, M.E.,Montalbetti, C.,Potin, D.,Poupardin, O.,Spitzer, L.; Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist; To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)