6SKH

X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a inhibitor sulfamide inhibitor GluAsp

Summary for 6SKH

Entry DOI	10.2210/pdb6skh/pdb
Descriptor	Glutamate carboxypeptidase 2, CHLORIDE ION, beta-D-mannopyranose, ... (15 entities in total)
Functional Keywords	glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; sulfamide, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	84329.36
Authors	Motlova, L.,Novakova, Z.,Barinka, C. (deposition date: 2019-08-15, release date: 2020-08-26, Last modification date: 2024-01-31)
Primary citation	Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C. Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024 Cited by PubMed: 38224368 DOI: 10.1021/acs.jcim.3c01542 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation