6SJM

Crystal structure of the Retinoic Acid Receptor alpha in complex with compound 24 (JP175)

6SJM の概要

• エントリーDOI: 10.2210/pdb6sjm/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2-[4-[3,5-bis(trifluoromethyl)phenyl]phenyl]ethanoic acid, ... (4 entities in total)
• 機能のキーワード: rxra, steroid hormone receptor, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27909.27

構造登録者

Chaikuad, A.,Pollinger, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2019-08-13, 公開日: 2019-09-18, 最終更新日: 2024-01-24)

• 主引用文献: Pollinger, J.,Schierle, S.,Gellrich, L.,Ohrndorf, J.,Kaiser, A.,Heitel, P.,Chaikuad, A.,Knapp, S.,Merk, D.; A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.; Acs Med.Chem.Lett., 10:1346-1352, 2019; PubMed: 31531208; DOI: 10.1021/acsmedchemlett.9b00306

実験手法

X-RAY DIFFRACTION (2.52 Å)