6SI5

T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one

Summary for 6SI5

Entry DOI	10.2210/pdb6si5/pdb
Descriptor	Farnesyl diphosphate synthase, 5-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylcarbonyl)-1-methyl-pyridin-2-one, SULFATE ION, ... (4 entities in total)
Functional Keywords	farnesyl diphosphate synthase, sterol biosynthesis, farnesyl pyrophosphate, homodimer, transferase
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	41826.04
Authors	Petrick, J.K.,Muenzker, L.,Schleberger, C.,Cornaciu, I.,Clavel, D.,Marquez, J.A.,Jahnke, W. (deposition date: 2019-08-08, release date: 2020-08-26, Last modification date: 2024-02-07)
Primary citation	Petrick, J.K.,Jahnke, W. Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019 Cited by DOI: 10.17192/z2019.0501 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.097 Å)

Structure validation