6SI5

T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one

6SI5 の概要

• エントリーDOI: 10.2210/pdb6si5/pdb
• 分子名称: Farnesyl diphosphate synthase, 5-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylcarbonyl)-1-methyl-pyridin-2-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: farnesyl diphosphate synthase, sterol biosynthesis, farnesyl pyrophosphate, homodimer, transferase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41826.04

構造登録者

Petrick, J.K.,Muenzker, L.,Schleberger, C.,Cornaciu, I.,Clavel, D.,Marquez, J.A.,Jahnke, W. (登録日: 2019-08-08, 公開日: 2020-08-26, 最終更新日: 2024-02-07)

• 主引用文献: Petrick, J.K.,Jahnke, W.; Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery; Thesis, 2019; DOI: 10.17192/z2019.0501

実験手法

X-RAY DIFFRACTION (2.097 Å)