6SFR

SOS1 in Complex with Inhibitor BI-68BS

Summary for 6SFR

• Entry DOI: 10.2210/pdb6sfr/pdb
• Related: 6SCM
• Descriptor: Son of sevenless homolog 1, IMIDAZOLE, 6,7-dimethoxy-~{N}-[(1~{R})-1-phenylethyl]quinazolin-4-amine, ... (4 entities in total)
• Functional Keywords: oncology, exchange factor, protein-ligand complex, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 115101.63

Authors

Kessler, D.,Fischer, G.,Ramharter, J. (deposition date: 2019-08-02, release date: 2020-08-26, Last modification date: 2021-06-02)

• Primary citation: Hofmann, M.H.,Gmachl, M.,Ramharter, J.,Savarese, F.,Gerlach, D.,Marszalek, J.R.,Sanderson, M.P.,Kessler, D.,Trapani, F.,Arnhof, H.,Rumpel, K.,Botesteanu, D.A.,Ettmayer, P.,Gerstberger, T.,Kofink, C.,Wunberg, T.,Zoephel, A.,Fu, S.C.,Teh, J.L.,Bottcher, J.,Pototschnig, N.,Schachinger, F.,Schipany, K.,Lieb, S.,Vellano, C.P.,O'Connell, J.C.,Mendes, R.L.,Moll, J.,Petronczki, M.,Heffernan, T.P.,Pearson, M.,McConnell, D.B.,Kraut, N.; BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.; Cancer Discov, 11:142-157, 2021; PubMed: 32816843; DOI: 10.1158/2159-8290.CD-20-0142

Experimental method

X-RAY DIFFRACTION (1.917 Å)