6SFB

EED in complex with a triazolopyrimidine

Summary for 6SFB

• Entry DOI: 10.2210/pdb6sfb/pdb
• Descriptor: Polycomb protein EED, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, GLYCEROL, ... (4 entities in total)
• Functional Keywords: methyltransferase eed prc2 epigenetic h3k27 wd40 inhibitor, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 85533.43

Authors

Read, J.A. (deposition date: 2019-08-01, release date: 2019-09-25, Last modification date: 2021-07-14)

• Primary citation: Read, J.A.,Tart, J.,Rawlins, P.B.,Gregson, C.,Jones, K.,Gao, N.,Zhu, X.,Tomlinson, R.,Code, E.,Cheung, T.,Chen, H.,Kawatkar, S.P.,Bloecher, A.,Bagal, S.,O'Donovan, D.H.,Robinson, J.; Rapid Identification of Novel Allosteric PRC2 Inhibitors.; Acs Chem.Biol., 14:2134-2140, 2019; PubMed: 31525019; DOI: 10.1021/acschembio.9b00468

Experimental method

X-RAY DIFFRACTION (1.52 Å)