6SF6

Crystal structure of the mAb 15A in complex with COMP-epitope P6

Summary for 6SF6

• Entry DOI: 10.2210/pdb6sf6/pdb
• Descriptor: COMP-reactive monoclonal antibody 15A Fab fragment, heavy chain, COMP-reactive monoclonal antibody 15A Fab fragment, light chain, P6 epitope of cartilage oligomeric matrix protein (COMP), ... (6 entities in total)
• Functional Keywords: cartilage oligomeric matrix protein, autoantibody, arthrogenicity, acpa, immune system
• Biological source: Mus musculus (House mouse); More
• Total number of polymer chains: 6
• Total formula weight: 104237.92

Authors

Dobritzsch, D.,Ge, C.,Holmdahl, R. (deposition date: 2019-08-01, release date: 2020-06-24, Last modification date: 2024-10-23)

• Primary citation: Ge, C.,Tong, D.,Loennblom, E.,Bibo, L.,Hagert, C.,Kastbom, A.,Gjertsson, I.,Dobritzsch, D.,Holmdahl, R.; Antibodies to cartilage oligomeric matrix protein in vivo are pathogenic and clinically relevant in rheumatoid arthritis; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)