6SF6

Crystal structure of the mAb 15A in complex with COMP-epitope P6

6SF6 の概要

• エントリーDOI: 10.2210/pdb6sf6/pdb
• 分子名称: COMP-reactive monoclonal antibody 15A Fab fragment, heavy chain, COMP-reactive monoclonal antibody 15A Fab fragment, light chain, P6 epitope of cartilage oligomeric matrix protein (COMP), ... (6 entities in total)
• 機能のキーワード: cartilage oligomeric matrix protein, autoantibody, arthrogenicity, acpa, immune system
• 由来する生物種: Mus musculus (House mouse); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 104237.92

構造登録者

Dobritzsch, D.,Ge, C.,Holmdahl, R. (登録日: 2019-08-01, 公開日: 2020-06-24, 最終更新日: 2024-01-24)

• 主引用文献: Ge, C.,Tong, D.,Loennblom, E.,Bibo, L.,Hagert, C.,Kastbom, A.,Gjertsson, I.,Dobritzsch, D.,Holmdahl, R.; Antibodies to cartilage oligomeric matrix protein in vivo are pathogenic and clinically relevant in rheumatoid arthritis; To Be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)