6SDS

HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A SULFONAMIDE INHIBITOR

Summary for 6SDS

Entry DOI	10.2210/pdb6sds/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, phenyl-(4-sulfamoylphenoxy)phosphinic acid, ... (5 entities in total)
Functional Keywords	carbonic anhydrase ii, zinc enzyme, sulfonamide inhibitor, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29745.87
Authors	Alterio, V.,De Simone, G.,Esposito, D. (deposition date: 2019-07-29, release date: 2020-06-10, Last modification date: 2024-01-24)
Primary citation	Nocentini, A.,Alterio, V.,Bua, S.,Micheli, L.,Esposito, D.,Buonanno, M.,Bartolucci, G.,Osman, S.M.,ALOthman, Z.A.,Cirilli, R.,Pierini, M.,Monti, S.M.,Di Cesare Mannelli, L.,Gratteri, P.,Ghelardini, C.,De Simone, G.,Supuran, C.T. Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. J.Med.Chem., 63:5185-5200, 2020 Cited by PubMed: 32364386 DOI: 10.1021/acs.jmedchem.9b02135 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.26 Å)

Structure validation