6SDD

Crystal structure of D1228V cMET bound by BMS-777607

Summary for 6SDD

Entry DOI	10.2210/pdb6sdd/pdb
Descriptor	Hepatocyte growth factor receptor, N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	kinase, inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35431.35
Authors	Collie, G.W.,Phillips, C. (deposition date: 2019-07-26, release date: 2019-08-14, Last modification date: 2019-10-02)
Primary citation	Collie, G.W.,Koh, C.M.,O'Neill, D.J.,Stubbs, C.J.,Khurana, P.,Eddershaw, A.,Snijder, A.,Mauritzson, F.,Barlind, L.,Dale, I.L.,Shaw, J.,Phillips, C.,Hennessy, E.J.,Cheung, T.,Narvaez, A.J. Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors. Acs Med.Chem.Lett., 10:1322-1327, 2019 Cited by PubMed: 31531204 DOI: 10.1021/acsmedchemlett.9b00276 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation