6SDD
Crystal structure of D1228V cMET bound by BMS-777607
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 309 | 34826.4 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | A | N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | non-polymer | 512.9 | 1 | Chemie (353) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 1038 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Val 1228 | Asp 1228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34826.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 605.0 | |
| All* | Total formula weight | 35431.3 |
