6SCM

SOS1 in Complex with Inhibitor BI-3406

6SCM の概要

• エントリーDOI: 10.2210/pdb6scm/pdb
• 分子名称: Son of sevenless homolog 1, IMIDAZOLE, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: oncology, exchange factor, protein-ligand complex, oncoprotein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58014.26

構造登録者

Kessler, D.,Fischer, G.,Ramharter, J. (登録日: 2019-07-24, 公開日: 2020-08-26, 最終更新日: 2024-05-15)

• 主引用文献: Hofmann, M.H.,Gmachl, M.,Ramharter, J.,Savarese, F.,Gerlach, D.,Marszalek, J.R.,Sanderson, M.P.,Kessler, D.,Trapani, F.,Arnhof, H.,Rumpel, K.,Botesteanu, D.A.,Ettmayer, P.,Gerstberger, T.,Kofink, C.,Wunberg, T.,Zoephel, A.,Fu, S.C.,Teh, J.L.,Bottcher, J.,Pototschnig, N.,Schachinger, F.,Schipany, K.,Lieb, S.,Vellano, C.P.,O'Connell, J.C.,Mendes, R.L.,Moll, J.,Petronczki, M.,Heffernan, T.P.,Pearson, M.,McConnell, D.B.,Kraut, N.; BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.; Cancer Discov, 11:142-157, 2021; PubMed: 32816843; DOI: 10.1158/2159-8290.CD-20-0142

実験手法

X-RAY DIFFRACTION (1.866 Å)