6SBU

X-ray Structure of Human LDHA with an Allosteric Inhibitor (Compound 3)

6SBU の概要

• エントリーDOI: 10.2210/pdb6sbu/pdb
• 分子名称: L-lactate dehydrogenase A chain, 4-[[4-[(5-chloranylthiophen-2-yl)carbonylamino]-1,3-bis(oxidanylidene)isoindol-2-yl]methyl]benzoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: ldha, oxidoreductase, oxidoreductase inhibitor, allosteric inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 298141.95

構造登録者

Friberg, A.,Puetter, V.,Nguyen, D.,Rehwinkel, H. (登録日: 2019-07-22, 公開日: 2020-06-10, 最終更新日: 2024-01-24)

• 主引用文献: Friberg, A.,Rehwinkel, H.,Nguyen, D.,Putter, V.,Quanz, M.,Weiske, J.,Eberspacher, U.,Heisler, I.,Langer, G.; Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A.; Acs Omega, 5:13034-13041, 2020; PubMed: 32548488; DOI: 10.1021/acsomega.0c00715

実験手法

X-RAY DIFFRACTION (2.91 Å)