6SBA

Crystal Structure of mTEAD with a VGL4 Tertiary Structure Mimetic

Summary for 6SBA

• Entry DOI: 10.2210/pdb6sba/pdb
• Descriptor: Transcriptional enhancer factor TEF-3, Vestigial like 4 (Drosophila), isoform CRA_a, GLYCEROL, ... (5 entities in total)
• Functional Keywords: hippo pathway, protein-protein interaction, macrocyclic peptide, tertiary structure mimetic, signaling protein
• Biological source: Mus musculus (House mouse); More
• Total number of polymer chains: 2
• Total formula weight: 28714.52

Authors

Adihou, H.,Grossmann, T.N.,Waldmann, H.,Gasper, R. (deposition date: 2019-07-19, release date: 2020-09-30, Last modification date: 2024-01-24)

• Primary citation: Adihou, H.,Gopalakrishnan, R.,Forster, T.,Gueret, S.M.,Gasper, R.,Geschwindner, S.,Carrillo Garcia, C.,Karatas, H.,Pobbati, A.V.,Vazquez-Chantada, M.,Davey, P.,Wassvik, C.M.,Pang, J.K.S.,Soh, B.S.,Hong, W.,Chiarparin, E.,Schade, D.,Plowright, A.T.,Valeur, E.,Lemurell, M.,Grossmann, T.N.,Waldmann, H.; A protein tertiary structure mimetic modulator of the Hippo signalling pathway.; Nat Commun, 11:5425-5425, 2020; PubMed: 33110077; DOI: 10.1038/s41467-020-19224-8

Experimental method

X-RAY DIFFRACTION (1.3 Å)