6SAL

ROR(gamma)t ligand binding domain in complex with allosteric ligand FM26

Summary for 6SAL

Entry DOI	10.2210/pdb6sal/pdb
Descriptor	Nuclear receptor ROR-gamma, 4-[(~{E})-[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methylideneamino]benzoic acid (3 entities in total)
Functional Keywords	nuclear receptor, allosteric, inverse agonist, inhibitor, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28802.63
Authors	de Vries, R.M.J.M.,Meijer, F.A.,Doveston, R.G.,Brunsveld, L. (deposition date: 2019-07-17, release date: 2019-12-25, Last modification date: 2024-01-24)
Primary citation	Meijer, F.A.,Doveston, R.G.,de Vries, R.M.J.M.,Vos, G.M.,Vos, A.A.A.,Leysen, S.,Scheepstra, M.,Ottmann, C.,Milroy, L.G.,Brunsveld, L. Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor gamma t (ROR gamma t) Inverse Agonists. J.Med.Chem., 63:241-259, 2020 Cited by PubMed: 31821760 DOI: 10.1021/acs.jmedchem.9b01372 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation