6S9B

EGFR-KINASE IN COMPLEX WITH COMPOUND 1

6S9B の概要

• エントリーDOI: 10.2210/pdb6s9b/pdb
• 分子名称: Epidermal growth factor receptor, 3-fluoranyl-~{N}-[1-(2-methyl-2-oxidanyl-propyl)benzimidazol-2-yl]-5-pyridin-3-yl-benzamide (2 entities in total)
• 機能のキーワード: egf receptor kinase mutant t790m, l858r, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37551.47

構造登録者

Bader, G. (登録日: 2019-07-12, 公開日: 2019-11-20, 最終更新日: 2024-05-15)

• 主引用文献: Engelhardt, H.,Bose, D.,Petronczki, M.,Scharn, D.,Bader, G.,Baum, A.,Bergner, A.,Chong, E.,Dobel, S.,Egger, G.,Engelhardt, C.,Ettmayer, P.,Fuchs, J.E.,Gerstberger, T.,Gonnella, N.,Grimm, A.,Grondal, E.,Haddad, N.,Hopfgartner, B.,Kousek, R.,Krawiec, M.,Kriz, M.,Lamarre, L.,Leung, J.,Mayer, M.,Patel, N.D.,Simov, B.P.,Reeves, J.T.,Schnitzer, R.,Schrenk, A.,Sharps, B.,Solca, F.,Stadtmuller, H.,Tan, Z.,Wunberg, T.,Zoephel, A.,McConnell, D.B.; Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.; J.Med.Chem., 62:10272-10293, 2019; PubMed: 31689114; DOI: 10.1021/acs.jmedchem.9b01169

実験手法

X-RAY DIFFRACTION (3.25 Å)