6S7H

Human CD73 (5'-nucleotidase) in complex with PSB12489 (an AOPCP derivative) in the closed state

Summary for 6S7H

• Entry DOI: 10.2210/pdb6s7h/pdb
• Descriptor: 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: nucleotide analog, en, 5nt, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 60025.15

Authors

Pippel, J.,Strater, N. (deposition date: 2019-07-04, release date: 2020-07-22, Last modification date: 2024-11-06)

• Primary citation: Bhattarai, S.,Pippel, J.,Meyer, A.,Freundlieb, M.,Schmies, C.,Abdelrahman, A.,Fiene, A.,Lee, S.Y.,Zimmermann, H.,El-Tayeb, A.,Yegutkin, G.G.,Strater, N.,Muller, C.E.; X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5'-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy; Adv Ther, 2019; DOI: 10.1002/adtp.201900075

Experimental method

X-RAY DIFFRACTION (1.85 Å)