6S7H

Human CD73 (5'-nucleotidase) in complex with PSB12489 (an AOPCP derivative) in the closed state

6S7H の概要

• エントリーDOI: 10.2210/pdb6s7h/pdb
• 分子名称: 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: nucleotide analog, en, 5nt, inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60025.15

構造登録者

Pippel, J.,Strater, N. (登録日: 2019-07-04, 公開日: 2020-07-22, 最終更新日: 2024-01-24)

• 主引用文献: Bhattarai, S.,Pippel, J.,Meyer, A.,Freundlieb, M.,Schmies, C.,Abdelrahman, A.,Fiene, A.,Lee, S.Y.,Zimmermann, H.,El-Tayeb, A.,Yegutkin, G.G.,Strater, N.,Muller, C.E.; X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5'-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy; Adv Ther, 2019; DOI: 10.1002/adtp.201900075

実験手法

X-RAY DIFFRACTION (1.85 Å)