6S75
Crystal structure of Nek7 bound to compound 51
Summary for 6S75
| Entry DOI | 10.2210/pdb6s75/pdb |
| Related | 6S73 6S76 |
| Descriptor | Serine/threonine-protein kinase Nek7, 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide (2 entities in total) |
| Functional Keywords | kinase, inhibitor, cell cycle |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 144143.31 |
| Authors | Nasir, N.,Bayliss, R. (deposition date: 2019-07-04, release date: 2020-06-10, Last modification date: 2024-01-24) |
| Primary citation | Byrne, M.J.,Nasir, N.,Basmadjian, C.,Bhatia, C.,Cunnison, R.F.,Carr, K.H.,Mas-Droux, C.,Yeoh, S.,Cano, C.,Bayliss, R. Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. Biochem.J., 477:1525-1539, 2020 Cited by PubMed: 32242624DOI: 10.1042/BCJ20200128 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
Download full validation report
