6S5Q

Strictosidine Synthase from Ophiorrhiza pumila in complex with (S)-1-isobutyl-2,3,4,9-tetrahydro-1H-beta-carboline

Summary for 6S5Q

Entry DOI	10.2210/pdb6s5q/pdb
Descriptor	Strictosidine synthase, (1~{S})-1-(2-methylpropyl)-2,3,4,9-tetrahydro-1~{H}-pyrido[3,4-b]indole (3 entities in total)
Functional Keywords	alkaloid, c-c bond, pictet-spenglerase, lyase
Biological source	Ophiorrhiza pumila
Total number of polymer chains	1
Total formula weight	36998.24
Authors	Eger, E.,Sharma, M.,Kroutil, W.,Grogan, G. (deposition date: 2019-07-02, release date: 2020-04-08, Last modification date: 2024-01-24)
Primary citation	Eger, E.,Simon, A.,Sharma, M.,Yang, S.,Breukelaar, W.B.,Grogan, G.,Houk, K.N.,Kroutil, W. Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet-Spengler Reactions. J.Am.Chem.Soc., 142:792-800, 2020 Cited by PubMed: 31909617 DOI: 10.1021/jacs.9b08704 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation