6S4R

The crystal structure of glycogen phosphorylase in complex with 11

Summary for 6S4R

• Entry DOI: 10.2210/pdb6s4r/pdb
• Descriptor: Glycogen phosphorylase, muscle form, (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-naphthalen-2-yl-1,3-thiazol-4-yl)oxane-3,4,5-triol, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• Functional Keywords: phosphorylase, inhibitor, c-beta-d-glucopyranosyl thiazole, transferase
• Biological source: Oryctolagus cuniculus (Rabbit)
• Total number of polymer chains: 1
• Total formula weight: 98042.96

Authors

Kyriakis, E.,Papaioannou, O.S.E.,Solovou, T.G.A.,Skamnaki, V.T.,Leonidas, D.D. (deposition date: 2019-06-28, release date: 2020-02-19)

• Primary citation: Kyriakis, E.,Karra, A.G.,Papaioannou, O.,Solovou, T.,Skamnaki, V.T.,Liggri, P.G.V.,Zographos, S.E.,Szennyes, E.,Bokor, E.,Kun, S.,Psarra, A.G.,Somsak, L.,Leonidas, D.D.; The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.; Bioorg.Med.Chem., 28:115196-115196, 2020; PubMed: 31767404; DOI: 10.1016/j.bmc.2019.115196

Experimental method

X-RAY DIFFRACTION (2.3 Å)