6S2I
Anti-tumor antibody 14F7-derived scFv in complex with NeuGc Gm3
Summary for 6S2I
| Entry DOI | 10.2210/pdb6s2i/pdb |
| Related | 6FFJ |
| Descriptor | scFv C1, N-glycolyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose (3 entities in total) |
| Functional Keywords | ganglioside, complex, scfv, antibody fragment, single chain fragment variable, immuno therapy, 14f7, antitumor protein, gm3 |
| Biological source | Mus musculus |
| Total number of polymer chains | 8 |
| Total formula weight | 225579.46 |
| Authors | Bjerregaard-Andersen, K.,Heggelund, J.E.,Krengel, U. (deposition date: 2019-06-20, release date: 2020-07-15, Last modification date: 2024-01-24) |
| Primary citation | Bjerregaard-Andersen, K.,Abraha, F.,Johannesen, H.,Oscarson, S.,Moreno, E.,Krengel, U. Key role of a structural water molecule for the specificity of 14F7-An antitumor antibody targeting the NeuGc GM3 ganglioside. Glycobiology, 31:1500-1509, 2021 Cited by PubMed: 34735569DOI: 10.1093/glycob/cwab076 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.285 Å) |
Structure validation
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