6S25

Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand

6S25 の概要

• エントリーDOI: 10.2210/pdb6s25/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, ~{tert}-butyl ~{N}-[3-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]propyl]carbamate, ... (4 entities in total)
• 機能のキーワード: bet, bromodomain, rt53, inhibitor, structural genomics, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15838.64

構造登録者

Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) (登録日: 2019-06-20, 公開日: 2019-07-31, 最終更新日: 2024-01-24)

• 主引用文献: Picaud, S.,Traquete, R.,Bernardes, G.J.L.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC); Crystal Structure of the first bromodomain of BRD4 in complex with a benzodiazepine ligand; To Be Published,

実験手法

X-RAY DIFFRACTION (1.1 Å)