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6S11

Crystal Structure of DYRK1A with small molecule inhibitor

Summary for 6S11
Entry DOI10.2210/pdb6s11/pdb
DescriptorDual specificity tyrosine-phosphorylation-regulated kinase 1A, CHLORIDE ION, 6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine, ... (4 entities in total)
Functional Keywordskinase, catalytic domain, phosphorylated, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight84911.13
Authors
Sorrell, F.J.,Henderson, S.H.,Redondo, C.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Elkins, J.M. (deposition date: 2019-06-18, release date: 2019-06-26, Last modification date: 2024-01-24)
Primary citationSorrell, F.J.,Henderson, S.H.,Elkins, J.M.,Ward, S.
Kinase Scaffold Repurposing in the Public Domain
To be published,
Experimental method
X-RAY DIFFRACTION (2.445 Å)
Structure validation

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