6RZ5
XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast
Summary for 6RZ5
Entry DOI | 10.2210/pdb6rz5/pdb |
Descriptor | Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, zafirlukast, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (7 entities in total) |
Functional Keywords | gpcr, lcp, membrane protein, cysteinyl leukotriene, ltd4, cyslt1, cysltr1, cyslt1r, asthma, zafirlukast, bril, sodium site, cysteinyl leukotriene receptor 1, xfel, serial femtosecond crystallography, sfx |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 109293.40 |
Authors | Luginina, A.,Gusach, A.,Marin, E.,Mishin, A.,Brouillette, R.,Popov, P.,Shiryaeva, A.,Besserer-Offroy, E.,Longpre, J.M.,Lyapina, E.,Ishchenko, A.,Patel, N.,Polovinkin, V.,Safronova, N.,Bogorodskiy, A.,Edelweiss, E.,Liu, W.,Batyuk, A.,Gordeliy, V.,Han, G.W.,Sarret, P.,Katritch, V.,Borshchevskiy, V.,Cherezov, V. (deposition date: 2019-06-12, release date: 2019-10-30, Last modification date: 2024-01-24) |
Primary citation | Luginina, A.,Gusach, A.,Marin, E.,Mishin, A.,Brouillette, R.,Popov, P.,Shiriaeva, A.,Besserer-Offroy, E.,Longpre, J.M.,Lyapina, E.,Ishchenko, A.,Patel, N.,Polovinkin, V.,Safronova, N.,Bogorodskiy, A.,Edelweiss, E.,Hu, H.,Weierstall, U.,Liu, W.,Batyuk, A.,Gordeliy, V.,Han, G.W.,Sarret, P.,Katritch, V.,Borshchevskiy, V.,Cherezov, V. Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Sci Adv, 5:eaax2518-eaax2518, 2019 Cited by PubMed: 31633023DOI: 10.1126/sciadv.aax2518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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