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6RZ5

XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast

6RZ5 の概要
エントリーDOI10.2210/pdb6rz5/pdb
分子名称Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, zafirlukast, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (7 entities in total)
機能のキーワードgpcr, lcp, membrane protein, cysteinyl leukotriene, ltd4, cyslt1, cysltr1, cyslt1r, asthma, zafirlukast, bril, sodium site, cysteinyl leukotriene receptor 1, xfel, serial femtosecond crystallography, sfx
由来する生物種Homo sapiens (Human)
詳細
タンパク質・核酸の鎖数2
化学式量合計109293.40
構造登録者
主引用文献Luginina, A.,Gusach, A.,Marin, E.,Mishin, A.,Brouillette, R.,Popov, P.,Shiriaeva, A.,Besserer-Offroy, E.,Longpre, J.M.,Lyapina, E.,Ishchenko, A.,Patel, N.,Polovinkin, V.,Safronova, N.,Bogorodskiy, A.,Edelweiss, E.,Hu, H.,Weierstall, U.,Liu, W.,Batyuk, A.,Gordeliy, V.,Han, G.W.,Sarret, P.,Katritch, V.,Borshchevskiy, V.,Cherezov, V.
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5:eaax2518-eaax2518, 2019
Cited by
PubMed: 31633023
DOI: 10.1126/sciadv.aax2518
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.53 Å)
構造検証レポート
Validation report summary of 6rz5
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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