6RZ3
Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP
Summary for 6RZ3
| Entry DOI | 10.2210/pdb6rz3/pdb |
| Descriptor | Cellular tumor antigen p53, RelA-associated inhibitor, ZINC ION (3 entities in total) |
| Functional Keywords | complex, p53, iaspp, antitumor protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 51857.63 |
| Authors | Chen, S.,Ren, J.,Jones, E.Y.,Lu, X. (deposition date: 2019-06-12, release date: 2019-10-30, Last modification date: 2024-01-24) |
| Primary citation | Chen, S.,Wu, J.,Zhong, S.,Li, Y.,Zhang, P.,Ma, J.,Ren, J.,Tan, Y.,Wang, Y.,Au, K.F.,Siebold, C.,Bond, G.L.,Chen, Z.,Lu, M.,Jones, E.Y.,Lu, X. iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition. Proc.Natl.Acad.Sci.USA, 116:17470-17479, 2019 Cited by PubMed: 31395738DOI: 10.1073/pnas.1909393116 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (4.23 Å) |
Structure validation
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