6RTO

Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1-[(dimethylamino)methyl]-2-naphthol at 4 hours of soaking

Summary for 6RTO

Entry DOI	10.2210/pdb6rto/pdb
Descriptor	Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, 1-methylidenenaphthalen-2-one, ... (5 entities in total)
Functional Keywords	fragment, secondary site, schistosomiasis, fad/nad linked reductase, flavoprotein, time-resolved structural studies
Biological source	Schistosoma mansoni
Total number of polymer chains	1
Total formula weight	66199.95
Authors	Angelucci, F.,Silvestri, I.,Fata, F.,Williams, D.L. (deposition date: 2019-05-24, release date: 2020-01-08, Last modification date: 2024-01-24)
Primary citation	Silvestri, I.,Lyu, H.,Fata, F.,Banta, P.R.,Mattei, B.,Ippoliti, R.,Bellelli, A.,Pitari, G.,Ardini, M.,Petukhova, V.,Thatcher, G.R.J.,Petukhov, P.A.,Williams, D.L.,Angelucci, F. Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radic Biol Med, 147:200-211, 2020 Cited by PubMed: 31870799 DOI: 10.1016/j.freeradbiomed.2019.12.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation