6RT2
Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules designed to investigate the water envelope
Summary for 6RT2
Entry DOI | 10.2210/pdb6rt2/pdb |
Related | 5OML |
Descriptor | Peroxin 14, (3~{S})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic acid, SULFATE ION, ... (5 entities in total) |
Functional Keywords | peroxisomal translocation, ppi inhibition, protein-inhibitor complex, signaling protein |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 4 |
Total formula weight | 34023.09 |
Authors | Napolitano, V.,Ratkova, E.L.,Dawidowski, M.,Dubin, G.,Fino, R.,Popowicz, G.,Sattler, M.,Tetko, I.V. (deposition date: 2019-05-22, release date: 2020-04-08, Last modification date: 2024-01-24) |
Primary citation | Ratkova, E.L.,Dawidowski, M.,Napolitano, V.,Dubin, G.,Fino, R.,Ostertag, M.S.,Sattler, M.,Popowicz, G.,Tetko, I.V. Water envelope has a critical impact on the design of protein-protein interaction inhibitors. Chem.Commun.(Camb.), 56:4360-4363, 2020 Cited by PubMed: 32195483DOI: 10.1039/c9cc07714f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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