6RSE
Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Summary for 6RSE
Entry DOI | 10.2210/pdb6rse/pdb |
Related | 6rsb 6rsc 6rsd |
Descriptor | Tyrosine-protein kinase JAK1, methyl ~{N}-[4-aminocarbonyl-1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate (3 entities in total) |
Functional Keywords | inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70442.11 |
Authors | Brown, D.G.,Lupardus, P.J. (deposition date: 2019-05-21, release date: 2020-07-08, Last modification date: 2024-10-16) |
Primary citation | Zak, M.,Gibbons, P.,Brown, D.G. Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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