6RRX

GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3R)-2-(Hydroxymethyl)-3-piperidinol

Summary for 6RRX

Entry DOI	10.2210/pdb6rrx/pdb
Descriptor	Alpha-mannosidase 2, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	mannosidase, glycoside hydrolase, hydrolase
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	1
Total formula weight	118528.72
Authors	Armstrong, Z.,Lahav, D.,Johnson, R.,Kuo, C.L.,Beenakker, T.J.M.,de Boer, C.,Wong, C.S.,van Rijssel, E.R.,Debets, M.,Geurink, P.P.,Ovaa, H.,van der Stelt, M.,Codee, J.D.C.,Aerts, J.M.F.G.,Wu, L.,Overkleeft, H.S.,Davies, G.J. (deposition date: 2019-05-20, release date: 2020-07-08, Last modification date: 2024-01-24)
Primary citation	Armstrong, Z.,Kuo, C.L.,Lahav, D.,Liu, B.,Johnson, R.,Beenakker, T.J.M.,de Boer, C.,Wong, C.S.,van Rijssel, E.R.,Debets, M.F.,Florea, B.I.,Hissink, C.,Boot, R.G.,Geurink, P.P.,Ovaa, H.,van der Stelt, M.,van der Marel, G.M.,Codee, J.D.C.,Aerts, J.M.F.G.,Wu, L.,Overkleeft, H.S.,Davies, G.J. Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142:13021-13029, 2020 Cited by PubMed: 32605368 DOI: 10.1021/jacs.0c03880 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation