6RPX

Cytokine receptor-like factor 3 C-terminus residues 174-442: native

6RPX の概要

• エントリーDOI: 10.2210/pdb6rpx/pdb
• 分子名称: Cytokine receptor-like factor 3 (2 entities in total)
• 機能のキーワード: platelet development, fibronectin domain, spry domain, blood clotting
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30057.35

構造登録者

Mifsud, R.W.,Yan, Y.,Bennett, C.,Read, R.J. (登録日: 2019-05-15, 公開日: 2020-03-25, 最終更新日: 2022-10-05)

• 主引用文献: Bennett, C.,Lawrence, M.,Guerrero, J.A.,Stritt, S.,Waller, A.K.,Yan, Y.,Mifsud, R.W.,Ballester-Beltran, J.,Baig, A.,Mueller, A.,Mayer, L.,Warland, J.,Penkett, C.J.,Akbari, P.,Moreau, T.,Evans, A.L.,Mookerjee, S.,Hoffman, G.J.,Saeb-Parsy, K.,Adams, D.J.,Couzens, A.L.,Bender, M.,Erber, W.N.,Nieswandt, B.,Read, R.J.,Ghevaert, C.; CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia.; Blood, 139:2227-2239, 2022; PubMed: 35051265; DOI: 10.1182/blood.2021013113

実験手法

X-RAY DIFFRACTION (1.61 Å)