6RPT
Structure of tick complement inhibitor CirpT1 complexed with macroglobubulin domain 4 of human complement C5
Summary for 6RPT
| Entry DOI | 10.2210/pdb6rpt/pdb |
| Related | 5HCC |
| Descriptor | Complement C5, Putative 8.9 kDa family member, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | complement, inhibitor, innate immunity, inflammation, c5, terminal pathway inhibitor, immunosuppressant |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 80849.24 |
| Authors | Reichhardt, M.P.,Lea, S.M.,Johnson, S. (deposition date: 2019-05-14, release date: 2020-01-08, Last modification date: 2024-01-24) |
| Primary citation | Reichhardt, M.P.,Johnson, S.,Tang, T.,Morgan, T.,Tebeka, N.,Popitsch, N.,Deme, J.C.,Jore, M.M.,Lea, S.M. An inhibitor of complement C5 provides structural insights into activation. Proc.Natl.Acad.Sci.USA, 117:362-370, 2020 Cited by PubMed: 31871188DOI: 10.1073/pnas.1909973116 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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