6RPT

Structure of tick complement inhibitor CirpT1 complexed with macroglobubulin domain 4 of human complement C5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	E, A, C	Complement C5	polymer	133	14511.4	3	UniProt (P01031) Pfam (PF17789) In PDB	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
2	F, B, D	Putative 8.9 kDa family member	polymer	113	12284.8	3	UniProt (L7MB58) Pfam (PF15430) In PDB	Rhipicephalus pulchellus
3	E, F, A, B, C	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
4		water	water		18.0	110	Chemie (HOH)

Sequence modifications

E, A, C: 348 - 460 (UniProt: P01031)

PDB	External Database	Details
Met 328	-	initiating methionine
Lys 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag
Ser 336	-	expression tag
Ala 337	-	expression tag
Gly 338	-	expression tag
Leu 339	-	expression tag
Glu 340	-	expression tag
Val 341	-	expression tag
Leu 342	-	expression tag
Phe 343	-	expression tag
Gln 344	-	expression tag
Gly 345	-	expression tag
Pro 346	-	expression tag
Met 347	-	expression tag

F, B, D: 4 - 92 (UniProt: L7MB58)

PDB	External Database	Details
Met -20	-	initiating methionine
Lys -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ala -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Glu -8	-	expression tag
Val -7	-	expression tag
Leu -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Pro -2	-	expression tag
Met -1	-	expression tag
Gly 0	-	expression tag
Asp 1	-	expression tag
Val 2	-	expression tag
Gln 3	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	80388.8
Non-Polymers*	Number of molecules	5
	Total formula weight	460.5
All*	Total formula weight	80849.2

*Water molecules are not included.