6ROY
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif
Summary for 6ROY
Entry DOI | 10.2210/pdb6roy/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM) (3 entities in total) |
Functional Keywords | phosphatase, inhibitory peptide, signal transducer, src homology-2 domains, cell cycle, immune receptor tyrosine-based inhibitory motif, itim |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 26379.26 |
Authors | Krausze, J.,Sikorska, J.,Carlomagno, T. (deposition date: 2019-05-13, release date: 2020-02-19, Last modification date: 2024-01-24) |
Primary citation | Marasco, M.,Berteotti, A.,Weyershaeuser, J.,Thorausch, N.,Sikorska, J.,Krausze, J.,Brandt, H.J.,Kirkpatrick, J.,Rios, P.,Schamel, W.W.,Kohn, M.,Carlomagno, T. Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6:eaay4458-eaay4458, 2020 Cited by PubMed: 32064351DOI: 10.1126/sciadv.aay4458 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report