6ROY

Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif

6ROY の概要

• エントリーDOI: 10.2210/pdb6roy/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM) (3 entities in total)
• 機能のキーワード: phosphatase, inhibitory peptide, signal transducer, src homology-2 domains, cell cycle, immune receptor tyrosine-based inhibitory motif, itim
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 26379.26

構造登録者

Krausze, J.,Sikorska, J.,Carlomagno, T. (登録日: 2019-05-13, 公開日: 2020-02-19, 最終更新日: 2024-01-24)

• 主引用文献: Marasco, M.,Berteotti, A.,Weyershaeuser, J.,Thorausch, N.,Sikorska, J.,Krausze, J.,Brandt, H.J.,Kirkpatrick, J.,Rios, P.,Schamel, W.W.,Kohn, M.,Carlomagno, T.; Molecular mechanism of SHP2 activation by PD-1 stimulation.; Sci Adv, 6:eaay4458-eaay4458, 2020; PubMed: 32064351; DOI: 10.1126/sciadv.aay4458

実験手法

X-RAY DIFFRACTION (2.1 Å)