6RNK
Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist NF-56-EJ40.
Summary for 6RNK
Entry DOI | 10.2210/pdb6rnk/pdb |
Related | 6IBB |
Descriptor | Succinate receptor 1, Nanobody6, 2-[2-[[3-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]carbonylamino]phenyl]ethanoic acid, ... (7 entities in total) |
Functional Keywords | sucnr1, gpr91, gpcr, g-protein coupled receptor, nanobody, antagonist, succinate, complex, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 60621.49 |
Authors | Haffke, M.,Jaakola, V.-P. (deposition date: 2019-05-08, release date: 2019-08-14, Last modification date: 2024-01-24) |
Primary citation | Haffke, M.,Fehlmann, D.,Rummel, G.,Boivineau, J.,Duckely, M.,Gommermann, N.,Cotesta, S.,Sirockin, F.,Freuler, F.,Littlewood-Evans, A.,Kaupmann, K.,Jaakola, V.P. Structural basis of species-selective antagonist binding to the succinate receptor. Nature, 574:581-585, 2019 Cited by PubMed: 31645725DOI: 10.1038/s41586-019-1663-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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